MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation
نویسندگان
چکیده
منابع مشابه
Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.
Ras homolog enriched in brain (Rheb) is a small GTPase that regulates cell growth, differentiation, and survival by upregulating mammalian target of rapamycin complex 1 (mTORC1) signaling. The role of Rheb/mTORC1 signaling in the activation of kidney fibroblasts and the development of kidney fibrosis remains largely unknown. In this study, we found that Rheb/mTORC1 signaling was activated in in...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2015
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2015.02.010